Benzomorphan derivatives

US4020164A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Dieter Rahtz · Berlin, DE
• Eberhard Schroder
• Reinhard Horowski
• Gert Paschelke
• Dieter Palenschat
• Helmut Wachtel · Berlin, DE
• Wolfgang Kehr

Key dates

• Filing date: Feb 18, 1975
• Grant date: Apr 26, 1977
• Expiry date: Feb 18, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D221/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Benzomorphans of the formula ##STR1## wherein R.sub.1 is H, CH.sub.3 or C.sub.2 H.sub.5 ; R.sub.2 is CH.sub.3 or C.sub.2 H.sub.5 and R.sub.3 and R.sub.4, which can be alike or different, each are lower alkyl, and the acid addition salts thereof with physiologically acceptable acids have CNS activity, including analgesic, morphine antagonistic, anti-convulsive, muscle relaxant, sedative and neuroleptic activity.