Derivatives of mitomycin C
US4021449A · kind A · utility
9Cited by
3References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 16, 1974 |
| Grant date | May 3, 1977 |
| Priority date | — |
| Expiry date | Dec 16, 1994 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
1A-Higher aliphatic acyl derivatives of mitomycin C have been found to have superior anti-tumor activity and lipid-solubility as compared with known 1a-acyl derivatives of mitomycin C. Also, the new derivatives exhibit far lower toxicity than mitomycin C. These derivatives are represented by the following formula: ##STR1## wherein R is an aliphatic hydrocarbon group having 9-29 carbon atoms or a group wherein a hydrogen atom of the aliphatic hydrocarbon group is substituted by a hydroxy group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.