Process for preparing polycyclic heterocycles having a pyran ring
US4021451A · kind A · utility
29Cited by
3References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 5, 1975 |
| Grant date | May 3, 1977 |
| Priority date | — |
| Expiry date | Jun 5, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/052
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process applicable to the preparation of a wide variety of novel polycyclic heterocycles having a newly-formed pyran ring is disclosed. According to the process an aromatic nucleus bearing an ethanol group, for example, 3,4-dimethoxyphenethyl alcohol, is condensed with an aldehyde or ketone or a protected aldehyde or ketone, for example, aminoactaldehyde diethyl acetal, in the presence of an acid catalyst to afford the polycyclic heterocycle, for example, 6,7-dimethoxy-1-isochromanmethylamine. The new heterocycles so formed are useful for preparing derivatives having antiinflammatory, antibacterial or antifungal activities.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.