Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
US4021478A · kind A · utility
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Key dates
| Filing date | Apr 23, 1976 |
| Grant date | May 3, 1977 |
| Priority date | — |
| Expiry date | Apr 23, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C51/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for preparing carboxylic acids by converting a glycidonitrile to a 2-oxopropionitrile via use of an ionic Lewis acid, and conversion of the 2-oxopropionitrile to the carboxylate salt with a base and of the salt to the carboxylic acid with acid. The process is especially useful for the preparation of 2-(p-isobutylphenyl)propionic acid, (lbuprofen), also known as Motrin, a known and highly active antiinflammatory agent as well as a host of other carboxylic acids which are known in the art as useful compounds.
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