Process for the production of carnitine
US4021480A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Sep 25, 1975 |
| Grant date | May 3, 1977 |
| Priority date | — |
| Expiry date | Sep 25, 1995 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/13
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The process for the production of carnitine hydrochloride which involves reacting an ester of .gamma.-halo-acetoacetic acid having the formula: ##STR1## R.sub.1 is a hydrogen, R.sub.2 is a lower alkyl group having 1 to 10 carbon atoms and X is halogen selected from the group consisting of chlorine or bromine, with an alkali alcoholate, which is present in a stoichiometrically excessive amount, at a temperature between 0.degree. and -40.degree. C. The reaction product is reacted with trimethylamine at a temperature between 10.degree. and 50.degree. C., a (3-carbalkoxy-2-oxopropyl)-trimethyl ammonium halide resulting. The (3-carbalkoxy-2-oxopropyl)-trimethyl ammonium halide is hydrogenated, a carnitine ester resulting. Then the carnitine ester is converted by means of aqueous hydrochloride acid into carnitine hydrochloride.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.