N,N'-bis-[(.beta.-hydroxy-.beta.-phenyl)-ethyl]-polymethylenediamines and salts thereof

US4021485A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Kurt Schromm · Ingelheim am Rhein, DE
• Anton Mentrup · Mainz, DE
• Ernst-Otto Renth · Ingelheim am Rhein, DE
• Werner Traunecker · Münster-Sarmsheim, DE

Key dates

• Filing date: Nov 4, 1975
• Grant date: May 3, 1977
• Expiry date: Nov 4, 1995

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## WHEREIN R.sub.1 is hydrogen or methyl, PA1 m is 0 or an integer from 1 to 8, inclusive, and PA1 Ar is ##STR2## WHERE R is hydrogen or acyl, and PA1 R.sub.2 is hydrogen or --OR, as defined above, ##STR3## WHERE R has the meanings defined above, and PA1 R.sub.3 is hydroxy-lower alkyl, --NH--CO--R.sub.4, --NH--SO.sub.2 --R.sub.5, --CH.sub.2 --NH--CO--R.sub.4, --CH.sub.2 --NH--SO.sub.2 --R.sub.5 or --CH.sub.2 --NH--CO--NH--R.sub.4, PA1 where PA1 R.sub.4 is hydrogen or lower alkyl, and PA1 R.sub.5 is lower alkyl or di-lower alkyl-amino, ##STR4## WHERE R.sub.6 is hydrogen, amino or hydroxyl, PA1 X is chlorine or bromine, and PA1 Y is hydrogen, chlorine or bromine PA1 or ##STR5## WHERE R has the meanings defined above, and PA1 A is a saturated or unsaturated 5- to 6-membered ring, And their non-toxic, pharmacologically acceptable acid addition salts; the compounds as well as their salts are useful as bronchospasmolytics, uterine spasmolytics, antipruritics and antiallergics.