Patent · US Expired

Substituted phenylisothioureas and processes for their preparation and use

US4021571A · kind A · utility

5Cited by

3References

20Claims

0Family size

Assignee

BAYER HEALTHCARE LLC · DE

Inventors

Heinrich Kolling · Haan, DE
Herbert Thomas
Arno Widdig · Odenthal, DE
Hartmund Wollweber · Wuppertal, DE

Key dates

Filing date	Jun 4, 1976
Grant date	May 3, 1977
Priority date	—
Expiry date	Jun 4, 1996

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C335/38
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

N-[2-(Substituted amido)phenyl]-N'-carbonyl-S-substituted isothioureas bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)-phenyl group are anthelmintic agents. The compounds, of which N-(2-acetamido-4-phenoxyphenyl)-N'-carbomethoxy-S-methylthiourea is a typical example, are prepared through the reaction of S-substituted N-(mercaptohalomethylene)carbamic acid ester and an appropriately substituted 2-aminoanilide, or through alkylation of the corresponding S-unsubstituted thiourea.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.