Carbamylguanidine antimicrobial compounds

US4022962A · kind A · utility

Assignee

• Cooper Laboratories, Inc. · US

Inventor

• Julius Diamond · Morristown, US

Key dates

• Filing date: Feb 3, 1975
• Grant date: May 10, 1977
• Expiry date: Feb 3, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C279/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Antimicrobial compounds are disclosed having the formula: EQU Z--B--Y--B'--Z .nHA wherein B is carbamylguaidino, or thiocarbamylguanidino and B' is B or biguanidino provided that B' is biguanidino only when B is carbamylguanidino bonded to Y through the guanidino portion of the group, Y is a bivalent organic radical selected from the group consisting of C.sub.2 -C.sub.12 alkylene, C.sub.5 -C.sub.12 cycloalkylene, C.sub.5 -C.sub.12 cycloalkylenebis(loweralkyl), C.sub.6 -C.sub.12 arylene and loweralkylarylene, C.sub.7 -C.sub.12 aryleneloweralkyl, and C.sub.8 -C.sub.12 arylenebis(loweralkyl) and Z is selected from the group consisting of C.sub.1 -C.sub.12 alkyl; C.sub.4 -C.sub.12 dialkylaminoalkyl; C.sub.3 -C.sub.12 alkenyl; C.sub.3 -C.sub.12 alkynyl; C.sub.3 -C.sub.12 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl; C.sub.1 -C.sub.10 alkoxy C.sub.10 -C.sub.2 alkyl having a total carbon content of C.sub.3 -C.sub.14 ; C.sub.1 -C.sub.10 alkylthio C.sub.10 -C.sub.2 alkyl having a total carbon content of C.sub.3 -C.sub.14 ; phenoxy C.sub.2 - C.sub.6 alkyl; phenylthio C.sub.2 -C.sub.6 alkyl; C.sub.6 -C.sub.14 aryl; C.sub.7 -C.sub.14 aralkyl and arylcycloalkyl; and C.sub.6 -C.sub.14 aryl and …