Antimycotic compositions containing an imidazolylacetic acid amide or salt thereof as the active agent and the use thereof in the treatment of mycoses

US4024270A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Jurgen Wenzelburger
• Karl H. Buchel · Burscheid, DE
• Manfred Plempel · Haan, DE
• Werner Meiser

Key dates

• Filing date: Jul 9, 1975
• Grant date: May 17, 1977
• Expiry date: Jul 9, 1995

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/415
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutical compositions useful for treating mycotic infections in humans and animals are produced which comprise an antimycotically effective amount of an imidazolylacetic acid amide of the formula: ##STR1## or pharmaceutically acceptable nontoxic salts thereof WHEREIN PA1 Either PA1 R.sup.1 is phenyl or cycloalkyl, unsubstituted or substituted by one or more substituents; and PA1 R.sup.2 is hydrogen; PA1 Or PA1 R.sup.1 and R.sup.2, together with the nitrogen atom to which they are attached, form a saturated 5 to 7-membered heterocyclic ring which ring may contain an --SO.sub.2 -- or --NY-- moiety wherein Y is alkoxycarbonyl, dialkylaminocarbonyl, or phenyl or diphenylmethyl, unsubstituted or substituted by one or more substituents and wherein said 5 to 7-membered heterocyclic ring itself is otherwise unsubstituted or substituted by one or more substituents; and PA1 X.sup.1, x.sup.2, x.sup.3 and X.sup.4 are the same or different and are each hydrogen or halogen, Are produced by PA1 A. reacting a halodiphenylacetic acid amide of the formula: ##STR2## wherein R.sup.1, R.sup.2, X.sup.1, X.sup.2, X.sup.3 and X.sup.4 are as above defined, and Hal is hydrogen, With imidazole; or PA1 …