Tetracyclic compounds

US4024272A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Werner Rogalski
• Richard Kirchlechner
• Jurgen Seubert · Darmstadt, DE
• Rudolf Gottschlich · Reinheim, DE
• Rosmarie Steinigeweg
• Rolf Bergmann
• Helmut Wahlig · Darmstadt, DE
• Joachim Gante · Darmstadt, DE

Key dates

• Filing date: Aug 26, 1975
• Grant date: May 17, 1977
• Expiry date: Aug 26, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D335/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Tetracyclic compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each are H or alkyl, R.sup.5 is H, F, Cl, Br, CF.sub.3, OH, alkyl, alkoxy, NO.sub.2, NH.sub.2, alkylamino, dialkylamino or acylamino and X is O, S, SO, SO.sub.2, NH, N-alkyl or N-acyl, alkyl and alkoxy in each case being of 1-3 carbon atoms and acyl in each case being of 1-4 carbon atoms, with the proviso that when R.sup.5 is methoxy and X is a sulfur atom, R.sup.5 is in the 8- or 9-position only, and their physiologically acceptable acid addition salts, possess broad spectrum antibacterial activity, including tetracycline-resistant Gram-positive and Gram-negative organisms.