Phenylalkylamines and phenylalkylureas in combinations to suppress gastric bleeding in aspirin therapy
US4025624A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 18, 1975 |
| Grant date | May 24, 1977 |
| Priority date | — |
| Expiry date | Nov 18, 1995 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/621
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel pharmaceutical methods, combinations and compositions for reducing gastric bleeding during aspirin therapy for inflammation are disclosed. Compounds used in combination with aspirin are phenylalkylamines and phenylalkylureas having the formula: ##STR1## wherein Z is selected from the group consisting of --NHR.sup.2 or ##STR2## and R is selected from the group consisting of hydrogen, halogen, lower-alkoxy and trifluoromethyl and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are selected from the group consisting of hydrogen and lower-alkyl, where R.sup.3 and R.sup.4 taken together with the adjacent nitrogen atom may form a heterocyclic ring selected from the group of piperidino, pyrrolidino, piperazino, and morpholino.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.