5- Or 6-pyridazinyl-benzimidazoles and salts thereof

US4026891A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Volkhard Austel · Biberach, DE
• Eberhard Kutter
• Joachim Heider · Warthausen, DE
• Wolfgang Eberlein · Biberach, DE
• Rudolf Kadatz · Zell am Harmersbach, DE
• Willi Diederen

Key dates

• Filing date: Jun 4, 1975
• Grant date: May 31, 1977
• Expiry date: Jun 4, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, trifluoromethyl, alkyl of 1 to 5 carbon atoms, mercapto, lower alkyl-mercapto, phenyl, fluoro-phenyl, tolyl, hydroxy-phenyl, methylmercapto-phenyl, methylsulfinyl-phenyl, methylsulfonyl-phenyl, dimethylamino-phenyl, or mono-, di- or tri-methoxy-substituted phenyl; PA1 A is hydrogen or, together with B, a double bond, PA1 B is hydrogen, alkyl of 1 to 3 carbon atoms or, together with A, a double bond; PA1 C is, together with R.sub.2, a double bond, or, together with R.sub.3, oxygen; PA1 R.sub.2 is hydrogen, alkyl of 1 to 3 carbon atoms or, together with C, a double bond; and PA1 R.sub.3 is chlorine, methylamino, morpholino, 4-methylpiperazino or, when R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms, together with C, oxygen; And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as hypotensives, antithrombotics and cardiotonics.