Aminocyclitol antibiotics
US4028188A · kind A · utility
6Cited by
2References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 21, 1976 |
| Grant date | Jun 7, 1977 |
| Priority date | — |
| Expiry date | Jan 21, 1996 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/865
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Aminocyclitol analogs of gentamicin C.sub.1, C.sub.2 and C.sub.1a and the corresponding compounds acylated on the 1-, 3- and 2'-amino groups with an .omega.-amino-.alpha.-hydroxy-lower-alkanoyl group are prepared by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and an added aminocyclitol with a mutant of Micromonospora purpurea and acylating the product with an ester of an .omega.-(N-benzyloxycarbonyl)amino-.alpha.-hydroxy-lower-alkanoic acid followed by catalytic hydrogenolysis of the benzyloxycarbonyl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.