6-Amino-5.beta.,19-cycloandrostane derivatives
US4028348A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 17, 1976 |
| Grant date | Jun 7, 1977 |
| Priority date | — |
| Expiry date | Feb 17, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J53/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel 6-amino-5.alpha.,19-cycloandrostane derivatives of formula I and their pharmaceutically acceptable addition salts ##STR1## wherein X denotes any of the groups of the formula =CH(OR), =CO or =C=N-OR.sub.1, PA1 Y denotes any of the groups of the formula =CO, =CH(OR.sub.1), =C=N-OR.sub.1, =C(OR.sub.1)-C.tbd.CH or ##STR2## wherein R denotes a hydrogen atom, a C.sub.1-4 alkyl group or a C.sub.2-5 acyl group, and PA2 R.sub.1 denotes a hydrogen atom, a straight-chained or branched C.sub.1-5 alkyl group, a straight-chained or branched C.sub.1-5 hydroxyalkyl group, a C.sub.3-8 cycloalkyl group, an allyl group, or a benzyl group, and PA1 R.sub.3 has the same meaning as R.sub.2 but if R.sub.2 is a sec. or tert. alkyl group or an alicyclic group, then R.sub.3 can only be a hydrogen atom; and if R.sub.2 is a benzyl group then R.sub.3 can only be a hydrogen atom or a primary alkyl group, further R.sub.2 and R.sub.3 may denote together with the adjcacent nitrogen atom a piperidine, a morpholine, or an N-methylpiperazine group. These compounds have exhibited an aldosterone-antagonistic effect on rats.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.