Novel derivatives of N-(3,4,5-trimethoxy cinnamoyl)piperazine and the process for preparing them

US4029650A · kind A · utility

Assignee

• Delalande S.A. · FR

Inventors

• Guy M. Raynaud · Paris, FR
• Bernard M. Pourrias · Rueil-Malmaison, FR
• Claude P. Fauran · Paris, FR
• Michel J. Turin · Paris, FR

Key dates

• Filing date: Nov 20, 1975
• Grant date: Jun 14, 1977
• Expiry date: Nov 20, 1995

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having the formula ##STR1## in which R.sub.1 is alkyl having no more than 4 carbon atoms and R.sub.2 is dimethoxyphenylethyl or ##STR2## is piperidino, heptamethyleneimino or 1,2,3,4-tetrahydroisoquinolino. The compounds are prepared by condensing N-(3,4,5-trimethoxy cinnamoyl)N'-(carboxymethyl) piperazine with ##STR3## The compounds possess peripheral, coronary and cerebral vasodilatory properties and an antihypertensive property.