Patent · US Expired

Nitro-.beta.-lactam antibiotics and processes for their preparation and use

US4029806A · kind A · utility

4Cited by

0References

13Claims

0Family size

Assignee

BAYER HEALTHCARE LLC · DE

Inventors

Wolfgang Krohn
Karl G. Metzger · Wuppertal, DE
Michael Preiss · Leinfelden, DE
Michael Walkowiak · Leverkusen, DE

Key dates

Filing date	Jul 22, 1976
Grant date	Jun 14, 1977
Priority date	—
Expiry date	Jul 22, 1996

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC10M2219/106
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Penicillin and cephalosporin derivatives characterized by the presence of a nitroalkyl, nitrocycloalkyl, nitrophenylalkyl or nitroanilinoalkyl group in the side chain are antibacterial agents. The compounds, of which 6-(2-nitro-3,3-dimethylbutyrylamido)-penicillanic acid, 7-nitroacetamido-3-methyl-ceph-3-em-4-carboxylic acid, and 6-[D-.alpha.-(2-nitro-2-methylpropionylamido)phenylacetamido] pencillanic acid are typical embodiments, are prepared by reacting 6-amino-penicillanic acid, 7-amino-cephalosporanic acid (or derivative thereof) or an .alpha.-substituted-.alpha.-amino-acetamido-penicillanic acid with an appropriate nitrated carboxylic acid or an equivalent nitrated acylating agent.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.