Antibacterial 3-phosphono penams
US4031077A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Apr 26, 1976 |
| Grant date | Jun 21, 1977 |
| Priority date | — |
| Expiry date | Apr 26, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65611
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention discloses novel 6-acylamino-2,2-dimethyl-3-phosphonopenams and certain lower alkyl esters thereof possessing antibacterial activity, methods for their production, and intermediates therefor; the production comprises the steps of reacting 6-triphenylmethylamino-2,2-dimethylpenam-3-carboxylic acid with lead tetraacetate to form the corresponding 3-acetoxy compound, the latter is converted to .alpha.-triphenylmethylamino-5,5-dimethyl-3-thiazoline-2-acetic acid which is condensed with dimethyl phosphite to produce .alpha.-triphenylmethylamino-5,5-dimethyl-4(0,0-dimethylphosphono)-thiazol idine-2-acetic acid which is cyclized to 6-triphenylmethylamino-2,2-dimethyl-3-(0,0-dimethylphosphono)penam and the latter is subsequently deblocked and acylated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.