Certain pleuromutilins

US4032530A · kind A · utility

Assignee

• Sandoz AG · CH

Inventors

• Helmut Egger · Wien, AT
• Hellmuth Reinshagen · Wien, AT

Key dates

• Filing date: Aug 21, 1975
• Grant date: Jun 28, 1977
• Expiry date: Aug 21, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C323/25
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to new pleuromutilins of the formula: ##STR1## wherein EITHER R.sub.1 is ethyl or vinyl, PA1 n is an integer from 2 to 5, PA1 X is sulphur, PA1 A group ##STR2## or a group =N-R.sub.4.sup.I, wherein PA2 Either Y and Z are both sulphur, or PA2 One of Y and Z is oxygen and the other is sulphur, and PA2 R.sub.4.sup.i is hydrogen or a group of the formula: ##STR3## wherein R.sub.1 is as defined above, EACH OF PA1 R.sub.2 and R.sub.3 is alkyl of 1 to 10 carbon atoms, or PA1 R.sub.2 and R.sub.3 together with the nitrogen atom form a heterocycle of 5 to 7 ring members containing one nitrogen atom or one nitrogen atom and a further hetero member selected from sulphur, oxygen and a group =N-R.sub.5.sup.I, PA1 wherein R.sub.5.sup.I is alkyl of 1 to 5 carbon atoms or hydroxyalkyl of 1 to 4 carbon atoms, or PA1 R.sub.2 and R.sub.3 together with the nitrogen atom form a piperazinyl radical, the second nitrogen atom of which is substituted by a radical R.sub.5.sup.II, PA1 whereby R.sub.5.sup.II is (acyloxy of 2 to 5 carbon atoms)alkyl of 1 to 4 carbon atoms or (benzoyloxy)alkyl of 1 to 4 carbon atoms, or PA1 Wherein R.sub.1 is as defined above, PA1 n is the number 2, PA1 R.…