Imidazolylacetic acid amides, their production, antimycotic compositions comprising said compounds and their use as antimycotic agents

US4032636A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Jurgen Wenzelburger
• Karl H. Buchel · Burscheid, DE
• Manfred Plempel · Haan, DE
• Werner Meiser

Key dates

• Filing date: Jan 22, 1976
• Grant date: Jun 28, 1977
• Expiry date: Jan 22, 1996

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/415
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Imidazolylacetic acid amides of the formula: ##STR1## or pharmaceutically acceptable nontoxic salts thereof wherein either R.sup.1 is phenyl or cycloalkyl, unsubstituted or substituted by one or more substituents; and PA1 R.sup.2 is hydrogen; or PA1 R.sup.1 and R.sup.2, together with the nitrogen atom to which they are attached, form a saturated 5 to 7-membered heterocyclic ring which ring may contain an --SO.sub.2 -- or --NY-- moiety wherein Y is alkoxycarbonyl, dialkylaminocarbonyl, or phenyl or diphenylmethyl, unsubstituted or substituted by one or more substituents and wherein said 5 to 7-membered heterocyclic ring itself is otherwise unsubstituted or substituted by one or more substituents; and PA1 X.sup.1, x.sup.2, x.sup.3 and X.sup.4 are the same or different and are each hydrogen or halogen, Are produced by A. reacting a halodiphenylacetic acid amide of the formula: ##STR2## wherein R.sup.1, R.sup.2, X.sup.1, X.sup.2, X.sup.3 and X.sup.4 are as above defined, and Hal is halogen, With imidazole; or B. reacting a halodiphenylacetic acid halide of the formula- ##STR3## WHEREIN X.sup.1, X.sup.2, X.sup.3 and X.sup.4 are as above defined and Hal is halogen With imidazole to produ…