Cyclization of peptides
US4033940A · kind A · utility
49Cited by
1References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 12, 1975 |
| Grant date | Jul 5, 1977 |
| Priority date | — |
| Expiry date | Nov 12, 1995 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/15
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The synthesis of a disulfide cyclic peptide by preparing an intermediate peptide containing an amino terminal cystine residue and a cysteine residue located in a position within the amino acid sequence, to give a desired peptide, and placing such intermediate peptide in a solution substantially free of oxygen at a pH of from about 5 to 10 until rearrangement takes place to yield a cyclic disulfide peptide and to displace a molecule of cysteine from the amino terminal cysteine residue. The disclosure also embraces said intermediate peptides as new compounds and the processes by which they are prepared.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.