Benzisothiazoline-1,1-dioxide derivatives, compositions and methods

US4038407A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Wolfgang Eberlein · Biberach, DE
• Eberhard Kutter
• Joachim Heider · Warthausen, DE
• Volkhard Austel · Biberach, DE
• Rudolf Kadatz · Zell am Harmersbach, DE
• Willi Diederen
• Walter Kobinger · Wien, AT
• Christian Lillie · Wien, AT
• Jurgen Dammgen · Sulmingen, DE

Key dates

• Filing date: Feb 24, 1976
• Grant date: Jul 26, 1977
• Expiry date: Feb 24, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D275/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl or phenyl, PA1 R.sub.2 is hydrogen, chlorine or methoxy, PA1 R.sub.3 is hydrogen or methoxy, PA1 R.sub.2 and R.sub.3, together with each other, are methylenedioxy or ethylenedioxy, PA1 R.sub.4 and R.sub.5 are each hydrogen or lower alkyl, PA1 R.sub.6 is hydrogen or lower alkoxy, PA1 R.sub.7 is lower alkoxy, PA1 R.sub.6 and R.sub.7, together with each other, are methylenedioxy or ethylenedioxy, PA1 X is carbonyl or sulfonyl, and PA1 n is 2 or 3, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful for slowing the heart rate.