Process for preparation of 3-halomethylcephems
US4042585A · kind A · utility
6Cited by
5References
31Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 22, 1976 |
| Grant date | Aug 16, 1977 |
| Priority date | — |
| Expiry date | Mar 22, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
3-Halomethyl-3-cephems are provided by reacting a 3-methylenecepham with an alkali metal salt of a lower alcohol or a bicyclic amidine base in the presence of a positive halogenating agent at a temperature ranging from -80.degree. to about 20.degree. C. The 3-halomethylcephems provided by this invention are useful intermediates for the preparation of known cephalosporin antibiotics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.