Process for preparing a 2-methyl-(substituted aryl)-pyruvic acid compound
US4042617A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 28, 1975 |
| Grant date | Aug 16, 1977 |
| Priority date | — |
| Expiry date | Jul 28, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D303/48
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing 3-methyl-3-(substituted aryl)-pyruvic acid compounds by treating a glycidic acid ester compound of the formula, ##STR1## wherein R.sup.1 is a 4-biphenylyl, 4-clyclohexylphenyl, 3-phenoxyphenyl, 4'-fluoro-4-biphenylyl, 2-fluoro-4-biphenylyl or 3-benzoylphenyl group and R.sup.2 is a lower alkyl group or its corresponding free acid with a Lewis acid to form a 2-hydroxy-3-(substituted aryl)-3-butenoic acid ester and treating the resulting ester in an alcohol with an alkali metal alcoholate to form the pyruvic acid compounds. If desired, the pyruvic acid compounds can then be saponified to compounds of the formula, ##STR2## wherein R.sup.1 is as previously defined and which compounds are useful as anti-inflammatory agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.