Aminoquinazoline therapeutic agents
US4044136A · kind A · utility
9Cited by
2References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 3, 1976 |
| Grant date | Aug 23, 1977 |
| Priority date | — |
| Expiry date | Mar 3, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/44
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A series of novel 2-amino and 4-aminoquinazoline derivatives have been prepared, including their acid addition salts. These derivatives all possess a single nitrogen-containing benzo-fused heterocyclic ring moiety at either the 4- or 2-positions of the molecule, respectively, with the ring moiety being attached through the nitrogen atom to the aforesaid quinazoline nucleus. Such compounds are useful in therapy as highly potent antihypertensive agents. Methods for their preparation are described in detail, including various synthetic routes leading to the required novel intermediates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.