1,4-Dihydropyridines

US4044141A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Friedrich Bossert
• Egbert Wehinger
• Kurt Stoepel · Wuppertal, DE
• Wulf Vater
• Stanislav Kazda · Wuppertal, DE

Key dates

• Filing date: Feb 2, 1976
• Grant date: Aug 23, 1977
• Expiry date: Feb 2, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/90
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

1,4-Dihydropyridines characterized by a carbo(arylalkoxy) group in the 5-position, an aryl group in the 4-position and a alkanoyl or carbalkoxy group in the 3-position and further optionally substituted in the 1,2 and 6-positions are coronary dilating, spasmolytic and hypotensive agents. The compounds, of which 2,6-dimethyl-3-carbomethoxy-4-(2-nitrophenyl)-5-carbobenzoxy-1,4-dihydropy ridine is a representative embodiment, are prepared through the reaction of an ylidene-.beta.-dicarbonyl compound, which may be generated in situ from the corresponding .beta.-dicarbonyl compound and an aldehyde, and an enaminocarboxylic acid ester, which may also be generated in situ from a .beta.-dicarbonyl compound and an amine.