Crosslinked copolymers of .alpha.,.beta.-olefinically unsaturated dicarboxylic anhydrides

US4044196A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Fritz Huper · Wuppertal, DE
• Erich Rauenbusch · Wuppertal, DE
• Gunter Schmidt-Kastner
• Bruno Bomer · Bensberg, DE
• Herbert Bartl · Odenthal, DE

Key dates

• Filing date: Dec 1, 1975
• Grant date: Aug 23, 1977
• Expiry date: Dec 1, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08F222/102
• WIPO field: Macromolecular chemistry, polymers
• WIPO sector: Chemistry

Abstract

There are disclosed water-insoluble proteinic preparations in which a protein or polypeptide is bound to a copolymer, which preparations are useful for binding enzymes in order to carry out enzyme-catalyzable reactions. These preparations comprise a peptide material bound to a cross-linked copolymer comprising the following copolymerized units: PA1 A. about 0.1 to 50 weight percent of at least one .alpha.,.beta. - monoolefinically unsaturated dicarboxylic acid anhydride having about 4 to 9 carbon atoms; PA1 B. about 99.9 to 50 weight percent of at least one di- and/or poly(meth)acrylate of a diol and/or a polyol as hereinafter defined, PA1 The copolymer having a bulk volume of 1.4 to 30 ml/g and a specific surface area of about 1 to 500 m.sup.2 /g, and containing, after saponification of the anhydride groups, about 0.02 to 10 milliequivalents of acid per gram.