D-Homo-20-ketopregnanes

US4045574A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Ulrich Kerb
• Rudolf Wiechert · Berlin, DE
• Klaus Kieslich · Braunschweig, DE
• Karl Petzoldt · Berlin, DE
• Helmut Wachtel · Berlin, DE
• Dieter Palenschat
• Reinhard Horowski
• Gert Paschelke
• Wolfgang Kehr

Key dates

• Filing date: Nov 29, 1974
• Grant date: Aug 30, 1977
• Expiry date: Nov 29, 1994

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P33/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

D-homo-20-ketopregnanes of the formula ##STR1## wherein R.sub.1 is oxygen, ##STR2## in which R.sub.5 is hydrogen or lower acyl; R.sub.2 is hydrogen or methyl; R.sub.3 is oxygen, ##STR3## or two hydrogen atoms; R.sub.4 is hydrogen, hydroxy or acyloxy; R.sub.6 is hydrogen or methyl; and R.sub.7 is hydrogen, acetyl, hydroxy or lower acyloxy in the .alpha.- or .beta.-position possess CNS-depressant activity, including anesthesia upon parenteral administration, and are produced by hydrogenating the corresponding steroids having double bonded C.sub.5 and/or C.sub.16 carbon atoms.