Daunomycin analogues, their preparation and use
US4046878A · kind A · utility
32Cited by
3References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 22, 1975 |
| Grant date | Sep 6, 1977 |
| Priority date | — |
| Expiry date | May 22, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/252
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Daunomycin analogues of the formula: ##STR1## wherein when each R.sub.1 is hydrogen, each R is hydrogen, chlorine, bromine, methyl or methoxy and when each R.sub.1 is chlorine, bromine or methyl, each R is hydrogen, are useful in treating various mammalian tumors and are prepared by reacting a daunomycinone derivative of the formula: ##STR2## wherein R and R.sub.1 are as defined above with 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy-.alpha.-L- lyxopyranose in an inert anhydrous organic solvent in the presence of a catalyst and a hydrogen chloride acceptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.