Novel N-allyl and N-propargyl benzmorphan derivatives
US4048178A · kind A · utility
2Cited by
2References
3Claims
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Assignee
Inventors
Key dates
| Filing date | Mar 10, 1960 |
| Grant date | Sep 13, 1977 |
| Priority date | — |
| Expiry date | Mar 10, 1980 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D221/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
N-Allyl-benzmorphan compounds having structures distinguished by having either a 4,5 or 6 carbon containing allyl group at the 2- or N-position or various ether derivatives of the 2'-hydroxy group. The compounds are prepared by alkylation of appropriate N-nor bases and have analgetic antagonist activity particularly pronounced in countering the effects of overdosing. Certain N-acyl-2'-hydroxy-5,9-dimethyl-6,7-benzmorphan intermediates are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.