Low toxicity method of inhibiting sickling of sickle erythrocytes

US4048325A · kind A · utility

Assignee

• The United States of America as represented by the United States Energy Research and Development Administration · US

Inventors

• Lester Packer · Berkeley, US
• Edwin N. Bymun · Oakland, US

Key dates

• Filing date: Jan 5, 1976
• Grant date: Sep 13, 1977
• Expiry date: Jan 5, 1996

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/21
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A low toxicity method of inhibiting sickling of sickle erythrocytes which comprises intermixing the erythrocytes with an effective anti-sickling amount of a water-soluble imidoester of the formula RC(=NH)OR' wherein R is an alkyl group of 1 - 8 carbon atoms, particularly 1 - 4 carbon atoms, and R' is an alkyl group of 1 - 4 carbon atoms, specifically methyl or ethyl acetimidate.