Preparation of N-(aminoalkyl)piperazine
US4049657A · kind A · utility
12Cited by
1References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 2, 1975 |
| Grant date | Sep 20, 1977 |
| Priority date | — |
| Expiry date | Jun 2, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/13
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved process for selectively preparing an N-(aminoalkyl)piperazine compound is disclosed wherein piperazine is contacted with a primary or secondary amino alkanol compound in the presence of a catalytically effective amount of a phosphorus-containing substance at a temperature of from about 250.degree. to about 350.degree. C under a pressure sufficient to maintain the mixture essentially in liquid phase and the N-(aminoalkyl)piperazine is then recovered from the resultant reaction mixture. In a preferred embodiment piperazine is contacted with monoethanolamine to produce N-(2-aminoethyl)-piperazine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.