Patent · US Expired

N'-substituted derivatives of 4'-(N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2'-dioxolane (1',3') their method of preparation and their application in therapeutics

US4049658A · kind A · utility

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Assignee

Delalande S.A. · FR

Inventors

Claude P. Fauran · Paris, FR
Guy M. Raynaud · Paris, FR
Michel J. Turin · Paris, FR
Janine M. Thomas · Neuilly, FR

Key dates

Filing date	Dec 6, 1976
Grant date	Sep 20, 1977
Priority date	—
Expiry date	Dec 6, 1996

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D317/72
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Compounds of the formula ##STR1## wherein Z is --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--, and R is methyl, ethoxycarbonylmethyl or ##STR2## wherein ##STR3## is methylamino, n-propylamino, isopropylamino, dimethylamino, di(n-propyl)amino, morpholino, pyrrolidino or hexamethyleneimino. The compounds are prepared by reacting piperazine substituted with R, with 4'-bromomethyl-5,2'-spiro-dibenzocycloheptadi(or tri)ene-(1',3') dioxolan. The compounds possess cough-suppressing, spasmolytic, analgesic, respiratory analeptic, hypotensive, vasodilatory, antiarythmic, antiulcerous, antihistamine, sedative, anti-inflammatory, diuretic and antiserotonine properties.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.