Tricyclic 1,2,4-triazolo-quinazolines

US4053600A · kind A · utility

Assignee

• Sandoz AG · CH

Inventors

• Goetz E. Hardtmann · Florham Park, US
• Faizulla G. Kathawala · West Orange, US

Key dates

• Filing date: Jun 25, 1975
• Grant date: Oct 11, 1977
• Expiry date: Jun 25, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/95
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention discloses 5-substituted-1,2,4-triazolo[4,3-c]quinazolines and 1,2,4-triazolo[1,5-c]quinazolines having pharmacological activity in animals and useful, for example, as hypotensive and anti-inflammatory agents. The compounds may be prepared, for example, by reacting a 5-halo-1,2,4-triazolo-quinazoline with a compound representing the function to be introduced at the 5-position. The 5-halo-1,2,4-triazolo[4,3-c]quinazolines also have pharmacological activity, e.g., hypotensive and anti-inflammatory activity, and may be prepared by reacting a 4-hydrazino-quinazoline with trimethoxy methane. The 5-halo-1,2,4-triazolo[1,5-c]quinazolines also have hypotensive and anti-inflammatory activity and are prepared from the corresponding 1,2,4-triazolo-[1,5-c]quinazolin-5(1H)-one using phosphorus oxychloride, the quinazolin-5(1H)-one being in turn prepared from the 5-halo-1,2,4-triazolo[4,3-c]quinazoline.