Patent · US Expired

1-Hydroxy-3-amino-alkane-1,1-diphosphonic acids and salts

US4054598A · kind A · utility

68Cited by

2References

4Claims

0Family size

Assignee

Henkel & Cie

Inventors

Helmut Blum · Goldkronach, DE
Karl-Heinz Worms

Key dates

Filing date	Jul 16, 1976
Grant date	Oct 18, 1977
Priority date	—
Expiry date	Jul 16, 1996

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC23F11/1676
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

1-Hydroxy-3-amino-alkane-1,1-diphosphonic acids having the formula ##STR1## wherein X is a member selected from the group consisting of ##STR2## and ##STR3## wherein R.sub.1 is a member selected from the group consisting of hydrogen and alkyl having 1 to 3 carbon atoms and R.sub.2 is alkyl having 1 to 3 carbon atoms; as well as their water-soluble salts. The 1-hydroxy-3-amino-alkane-1,1-diphosphonic acids are excellent sequestering agents especially for alkaline earth metal ions. The compounds are useful in pharmaceutical preparations for treatment of disturbances of calcium or phosphate metabolism or cosmetic preparations such as toothpastes or mouthwashes for the prevention of tartar and plaque depositions.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.