Process for preparing pregn-20-yne compounds and novel product produced thereby
US4055562A · kind A · utility
3Cited by
1References
11Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 28, 1976 |
| Grant date | Oct 25, 1977 |
| Priority date | — |
| Expiry date | May 28, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/0063
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing 17.beta.-hydroxysteroido[2,3-d]isoxazoles substituted at the 17.alpha.-position by an ethynyl or substituted ethynyl group comprising reacting a 17-oxosteroido[2,3-d]isoxazole with the appropriate ethynylmagnesium halide, substituted ethynylmagnesium halide, monolithium acetylide or substituted monolithium acetylide. The process affords a novel compound, 21-trifluoromethyl-17.alpha.-pregn-4-en-20-yno[2,3-d]isoxazol-17-ol, which has estrogenic activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.