Patent · US Expired

D-homo-20-ketopregnanes and method for inducing anesthesia or narcosis

US4056633A · kind A · utility

4Cited by

1References

37Claims

0Family size

Assignee

SCHERING CORPORATION · US

Inventors

Ulrich Kerb
Rudolf Wiechert · Berlin, DE
Helmut Wachtel · Berlin, DE
Otto Engelfried
Klaus Kieslich · Braunschweig, DE

Key dates

Filing date	Dec 17, 1975
Grant date	Nov 1, 1977
Priority date	—
Expiry date	Dec 17, 1995

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07J71/001
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

D-homo-20-ketopregnanes of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, alkyl, alkoxy, or azido; R.sub.2 is oxygen, ##STR2## and R.sub.7 is hydrogen, lower alkyl, or acyl of up to 5 carbon atoms; R.sub.3 is hydrogen or methyl R.sub.4 is oxygen, two hydrogens, ##STR3## R.sub.5 is hydrogen, hydroxy, alkoxy, azido, mercapto, thiocyano, cyano, dialkylamino, morpholino, thiomorpholino, or piperazino; R.sub.6 is methyl or ethyl; The hydrogen atom in the 5-position is of the .alpha.- or .beta.-configuration; And acid addition salts thereof, possess narcotic-anesthetic activity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.