Method for isolation of 3-hydroxy steroids and 3-keto steroids

US4057541A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Alfred Weber · Wien, AT
• Rudolf Muller · Frankfurt, DE
• Johannes Kurzidim · Berlin, DE

Key dates

• Filing date: Jun 25, 1976
• Grant date: Nov 8, 1977
• Expiry date: Jun 25, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J1/0022
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An improved process for isolating 3-hydroxy steroids and 3-keto steroids from mixtures thereof with lipids by dissolving the mixtures in an organic solvent, mixing the dissolved mixture with a metal salt to form insoluble adducts of the steroids, separating the insoluble adducts and splitting the adducts to regenerate the free steroids, which comprises using methyl isobutyl ketone and/or methyl n-amyl ketone as the solvent and calcium bromide as the metal salt.