Chiral 2-substituted-4-hydroxy-2-cyclopenten-1-one
US4057851A · kind A · utility
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Key dates
| Filing date | May 20, 1976 |
| Grant date | Nov 8, 1977 |
| Priority date | — |
| Expiry date | May 20, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C67/31
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for stereospecifically preparing chiral 2-substituted-4-hydroxy-2-cyclopenten-1-one which comprises asymmetrically reducing 2-substituted cyclopentane-1,3,4-trione to the corresponding 2-substituted-4(R)-hydroxy-cyclopentane-1,3-dione, enolizing the said dione to obtain the enol ester or enol ether configuration, reducing the enol ester or ether and recovering the desired compound. The chiral 2-substituted-4-hydroxy-2-cyclopenten-1-one are key intermediates in the preparation of prostaglandins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.