Aromatic keto acids and derivatives having analgetic, antiinflammatory, and hypocholesterolemizing action
US4058558A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 21, 1975 |
| Grant date | Nov 15, 1977 |
| Priority date | — |
| Expiry date | Mar 21, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C59/90
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to new chemical compounds useful as drugs, as well as to pharmaceutical compositions containing the same. The new products are aromatic keto acid compounds with antiinflammatory as well as analgetic and hypocholesteremic activity and having the general formula ##STR1## wherein R.sub.1 is hydrogen, halogen, phenyl, halophenyl, phenoxy, or substituted phenoxy. PA1 R.sub.2 is hydrogen or alkoxy. PA1 R.sub.1 and R.sub.2 may form a ring, for instance: phenyl or cyclohexyl. PA1 R.sub.3 is always other than hydrogen, being either methyl (CH.sub.3) or methylene. When R.sub.3 is CH.sub.3, a double bond is present between the A and B carbons. When R.sub.3 is a methylene connected by a double bond to the B carbon, there can be only a single bond between the A and B carbons. The remaining valences of the A carbon atom are satisfied by hydrogen atoms. PA1 R.sub.4 may be OH, alkoxy, ##STR2## The drugs containing these active principles are useful in the prevention and treatment of inflammatory syndromes, pain, and conditions involving excess cholresterol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.