2-[N-(1,3-diamino-isopropyl)-amino]-4-phenyl-2-imidazolines and salts thereof

US4058616A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Werner Kummer · Ingelheim am Rhein, DE
• Helmut Stahle
• Herbert Koppe · Ingelheim am Rhein, DE
• Walter Haarmann
• Richard Reichl · Ingelheim am Rhein, DE

Key dates

• Filing date: Jun 3, 1976
• Grant date: Nov 15, 1977
• Expiry date: Jun 3, 1996

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P7/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound of the formula ##STR1## wherein R.sub.1 is chlorine, bromine, fluorine or methyl; PA1 R.sub.2 and R.sub.3, which may be identical to or different from each other, are each hydrogen, chlorine or methyl; PA1 R.sub.4 is hydrogen, methyl or ethyl; and PA1 R.sub.5 and R.sub.6, which may be identical to or different from each other, are each methyl, ethyl or alkoxy-alkyl of 2 to 4 carbon atoms or, together with each other and the nitrogen atom to which they are attached, form a 5-, 6- or 7-membered heterocycle which may contain an additional heteroatom, such as pyrrolidino, piperidino, morpholino, piperazino or hexamethyleneimino; And non-toxic, pharmaceutically acceptable acid addition salts thereof; the compounds as well as the salts are useful as antithrombotics.