7-Diacyl cephalosporins
US4058661A · kind A · utility
11Cited by
3References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 7, 1975 |
| Grant date | Nov 15, 1977 |
| Priority date | — |
| Expiry date | Apr 7, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/28
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New 7-diacylimido cephalosporins are produced by reacting 7-acylamido cephalosporins with an acylating agent in the presence of a silyl reagent. The 7-diacylimido cephalosporins are cleaved to produce cephalosporins containing a different acylamido moiety. Thus, the aminoadipoyl group of cephalosporins produced by fermentation is replaced by a different acyl group by the process of the present invention. The cephalosporins produced are antibiotics having enhanced activity against gram-negative and gram-positive pathogens.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.