Production of N,N-Bis-(2-hydroxyalkyl)-aminomethane phosphonic acid dialkyl esters

US4060571A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Manfred Kapps · Bensberg, DE
• Karl-Heinz Mitschke · Odenthal, DE
• Reinhard Schliebs

Key dates

• Filing date: Feb 6, 1976
• Grant date: Nov 29, 1977
• Expiry date: Feb 6, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/4006
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the production of N,N-bis-(2-hydroxyalkyl)-aminomethane phosphonic acid dialkyl esters of the formula ##STR1## in which R is an optionally substituted alkyl radical with 2 to 10 carbon atoms, and PA1 R' is hydrogen or a lower alkyl radical with up to 6 carbon atoms, Comprising reacting an oxazolidine of the formula ##STR2## with a dialkyl phosphite in the presence of an acid ion exchanger. Preferably R is ethyl or isopropyl, R' is hydrogen or methyl, the ion exchanger is a sulfonated polystyrene resin and the reaction is effected at about 30.degree. to 120.degree. C, especially 60.degree. to 100.degree. C. The products are thereby obtained rapidly in higher purity than heretofore possible.