1,2,4-Triazole antimycotic compositions and use thereof

US4060623A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Werner Meiser
• Wolfgang Kramer · Wuppertal, DE
• Karl H. Buchel · Burscheid, DE
• Manfred Plempel · Haan, DE

Key dates

• Filing date: Jan 2, 1976
• Grant date: Nov 29, 1977
• Expiry date: Jan 2, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Antimycotic compositions are produced which comprise an antimycotically effective amount of a 1,2,4-triazole of the formula: ##STR1## or a pharmaceutically acceptable non-toxic salt thereof wherein X.sup.1 is hydrogen or alkyl; PA1 X.sup.2 is hydrogen or alkyl; PA1 R.sup.1 is alkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl; PA1 R.sup.2 is hydrogen, alkyl or unsubstituted or substituted aryl; PA1 R.sup.3 is alkyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl; and PA1 Y is a keto group or a functional derivative of a keto group, in combination with a pharmaceutically acceptable non-toxic, inert diluent or carrier.