Cyano acetic acid anilide derivatives, process for their manufacture and compositions containing these compounds
US4061767A · kind A · utility
45Cited by
2References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 3, 1976 |
| Grant date | Dec 6, 1977 |
| Priority date | — |
| Expiry date | Jun 3, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D261/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A 2-hydroxyethylidene-cyano acetic acid anilide is prepared by heating an acetoacetic acid anilide with an orthoformic acid ester and acetic anhydride, isolating the resulting 2-alkoxymethylene-acetoacetic acid anilide and treating it with hydroxylamine and the isoxazole so obtained with a base, and optionally reacting the resulting alkali metal or ammonium salt with a mineral acid or a strong organic acid. The compounds of the invention have anti-inflammatory and analgesic activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.