Process for preparing hypotensive 2-(4-aroylpiperazin-1-yl)-amino-6,7-dimethoxyquinazolines
US4062844A · kind A · utility
5Cited by
1References
7Claims
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Key dates
| Filing date | Sep 20, 1976 |
| Grant date | Dec 13, 1977 |
| Priority date | — |
| Expiry date | Sep 20, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/95
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Certain 2-(4-aroylpiperazin-1-yl)-4-amino-6,7-dimethoxyquinazolines are prepared by a novel process wherein certain 2-(4-substituted-piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline intermediates wherein said substituent is cyano, certain carbon-oxygen double bond containing groups or certain carbon-nitrogen double bond containing groups, are reacted with certain metalloaryl compounds followed by hydrolysis. The products are known hypotensive agents. Certain of the process intermediates are novel compounds.
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