Thiazolo[3,4-b]isoquinoline derivatives and pharmaceutical compositions containing them
US4064247A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 5, 1976 |
| Grant date | Dec 20, 1977 |
| Priority date | — |
| Expiry date | Aug 5, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D217/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Thiazolo[3,4-b]isoquinoline derivatives of the general formula: ##STR1## wherein A represents 3-pyridyl, 4-pyridyl or 5-isoquinolyl and, when A represents 3-pyridyl, X.sub.1 represents hydrogen, halogen, dimethylamino or cyano, X.sub.2 represents hydrogen or fluorine and X.sub.3 represents hydrogen or nitro, at least two of X.sub.1, X.sub.2 and X.sub.3 representing hydrogen, or X.sub.1 X.sub.2 together represent methylenedioxy and X.sub.3 represents hydrogen, and when A represents 4-pyridyl or 5-isoquinolyl, X.sub.1, X.sub.2 and X.sub.3 each represent hydrogen, and non-toxic pharmaceutically acceptable acid addition salts thereof, possess useful pharmacodynamic properties, in particular analgesic and antipyretic activity. This invention relates to new therapeutically useful thiazolo[3,4-b]isoquinoline derivatives, to processes for their preparation and to pharmaceutical compositions containing them. The new thiazolo[3,4-b]isoquinoline derivatives of the present invention are those of the general formula: ##STR2## wherein A represents a heterocyclic radical containing one nitrogen atom, selected from 3-pyridyl, 4-pyridyl and 5-isoquinolyl and, when A represents a 3-pyridyl radical, …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.