Process for preparing 2-guanidinomethyl-perhydroazocine-sulfate
US4065450A · kind A · utility
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2References
3Claims
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Assignee
Inventors
Key dates
| Filing date | Feb 26, 1976 |
| Grant date | Dec 27, 1977 |
| Priority date | — |
| Expiry date | Feb 26, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D225/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a novel process for preparing 2-guanidinomethyl-perhydroazocine-sulfate of formula I ##STR1## comprising the steps of catalytically reducing the 2-nitromethylene-perhydroazocine of formula IV ##STR2## in solution in acetone at a temperature of 20.degree. to 50.degree. C, treating the separated reaction product with an aqueous mineral acid and then reacting it with S-methyl-isothiocarbamid-sulfate. The process gives the desired end-product of formula I also on industrial scales.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.