Process for the preparation of 1,3-oxygenated 8.alpha.-estratrienes and novel intermediates obtained therefrom

US4066674A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Ulrich Eder · Berlin, DE
• Gerhard Sauer · Berlin, DE
• Gregor Haffer · Berlin, DE
• Guenter Neef · Berlin, DE
• Rudolf Wiechert · Berlin, DE

Key dates

• Filing date: Nov 12, 1976
• Grant date: Jan 3, 1978
• Expiry date: Nov 12, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J1/0074
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel 1,3-dialkoxy 8.alpha.-estratriene compounds of the formula ##STR1## WHEREIN R.sub.1 is alkyl of 1-18 carbon atoms, R.sub.2 is alkyl of 1-5 carbon atoms and Ac is alkanoyl of 1-8 carbon atoms, are obtained by a three-step synthesis from a tetrahydroindane-5-one compound.