New benzhydrysulphinyl derivatives

US4066686A · kind A · utility

Assignee

• Laboratoire L. Lafon · FR

Inventor

• Louis Lafon · Paris, FR

Key dates

• Filing date: Sep 30, 1976
• Grant date: Jan 3, 1978
• Expiry date: Sep 30, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides the benzhydrylsulphinyl derivatives of the formula: EQU (C.sub.6 H.sub.5).sub.2 CH--SO--(CH.sub.2).sub.n --R I where n is 1, 2 or 3 and R is C(.dbd.O)NHOH, C(.dbd.NH)NH.sub.2, C(.dbd.NH)NHOH, 2-.DELTA..sup.2 -imidazolinyl or NR.sub.1 R.sub.2 (where R.sub.1 is H or C.sub.1 -C.sub.3 -alkyl and R.sub.2 is H, C.sub.1 -C.sub.3 -alkyl, or CH.sub.2 CH.sub.2 OH, and R.sub.1 and R.sub.2 considered together can form, with the nitrogen atom to which they are bonded, a N-heterocyclic group of 5 to 7 ring members, which can be substituted and can contain a second hetero-atom such as O and N), and their addition salts. These products are useful in therapy for treating disturbances of the central nervous system.