Process and composition for determining the activity of creatinekinase-MB

US4067775A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Uwe Wurzburg · Dieburg, DE
• Norbert Hennrich
• Hans-Dieter Orth · Emmelshausen, DE
• Hermann Lang

Key dates

• Filing date: Nov 1, 1976
• Grant date: Jan 10, 1978
• Expiry date: Nov 1, 1996

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S436/815
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A process for determination of CK-MB activity in a sample of a body fluid comprising the steps of incubating the sample, optionally in the presence of CK substrates, with antibodies which inhibit enzymatic activity of the M subunit in CK isoenzymes MM and MB without inactivating enzymatic activity of the B subunit in any CK-MB which may be present and determining the activity of the CK B subunit in the resultant sample.